Adequan (polysulfated glycosaminoglycan [PSGAG]) is given by subcutaneous injection for arthritis. In joint tissue, PSGAG inhibits proteolytic enzymes that can degrade constituents of the cartilage, increases the synthesis of proteoglycans, reduces inflammation by reducing concentrations of prostaglandin E2 (released in response to joint injury), and increases hyaluronate concentrations in the joint, thereby restoring synovial fluid viscosity. With Adequan you should see signs of improvement within four weeks. The medication is generally given twice weekly for 4 weeks, then once weekly for 4 weeks, then every other week for 6 weeks, and then every 3 to 4 weeks long term. It can be given in combination with other arthritis medications for optimal effectiveness.
The injectable 5mL vile of Adequan includes 20 1mL syringes and size 22 and 25 gauge needles. Adequan is labeled for dogs and horses, but even though off label, also effective in cats. No side effects have been determined.